Doctorate and Master’s Degree
1. Mandatory Disciplines (4 Credit Units, 60 Credit Hours)
Biostatistics (4 Credit Units, 60 Credit Hours)
Syllabus: Concept. Planning in medical research. Collection, calculation and summary of the data. Measures of central tendency, dispersion and shape. Distribution of probabilities. Estimation of parametric and non-parametric data. Analysis of variance. Multivariate analysis: linear and logistic regressions. Survival analysis: Kaplan-Meier, Cox-Mantel and Haenszel. Evidence-based medicine decision making. Size of samples and data transformations.
Applied Epidemiology (4 Credit Units, 60 Credit Hours)
Syllabus: Epidemiology: basic concepts. Measures of frequency of diseases. Epidemiological surveillance. Demographic and epidemiological transition. Measures of effect and measures of association. Methods used in epidemiology: descriptive and analytical studies. Statistical association in epidemiology. Health information systems. Dynamics of disease transmission. Emerging and reemerging diseases.
2. Elective Disciplines (2 Credit Units, 30 Credit Hours)
Endocrine Disorders in Infectious Diseases (2 Credit Units, 30 Credit Hours)
Syllabus: Group discussion and seminars on updated original scientific articles.
Toxicological Aspects of Drugs Used in the Treatment of Tropical Diseases (2 Credit Units, 30 Credit Hours)
Syllabus: Introduction to Toxicology. Kinetics of drugs. Study of the harmful effects on the therapeutic and toxic doses of the drugs used in the treatment of malaria, intestinal helminthiases and protozooses, Chagas' disease, leishmaniasis, leprosy, human rabies. Fundamentals of therapeutic drug monitoring.
Molecular Biology Applied to the Study of Tropical Diseases (2 Credit Units, 30 Credit Hours)
Syllabus: Structure of nucleic acid molecules. DNA in the diagnosis of diseases. Recombinant DNA and its advantages. Hybridization of nucleic acids. Strategies for obtaining a probe. Bank selection to isolate a specific fragment. Evolution of diagnostic methods based on DNA analysis and its advantages. Principles of gene therapy and other therapies based on molecular genetics and treatment with recombinant proteins or genetically engineered vaccines. Molecular biology techniques used in epidemiological studies. Advantages and disadvantages of its applicability within the Amazon region. Interpretation, synthesis, analysis and discussion of molecular biology texts, basic and applied.
Cancer and Infectious Agents (2 Credit Units, 30 Credit Hours)
Syllabus: Study of oncogenesis caused by infectious agents, their molecular mechanisms and the involvement of the microenvironment.
Thesis Development (8 Credit Units, 120 Credit Hours)
Syllabus: Thesis Development.
Structure and Ultra-Structure of Protozoan Parasites (2 Credit Units, 30 Credit Hours)
Syllabus: Structure of parasitic protozoa. Structure and means of locomotion of flagellated protozoa. Ultrastructure of flagellated protozoa. Structure and means of locomotion of ciliated protozoa. Cystic protozoan structure. Structure and ultrastructure of protozoa of Filo Apicomplexa. Structure and means of locomotion of amebid protozoa. The structure of amebid protozoa. Mechanism of interaction of parasitic protozoa with the host cell. General principles of cell signaling for the establishment of parasitosis. The surface role and dynamism of cytoskeletal protein polymerization for the establishment of parasitosis.
Quantitative Studies in Collective Health (2 Credit Units, 30 Credit Hours)
Syllabus: Quantitative analysis of epidemiological data with the application of software.
Ethics in Research with Human Beings (2 Credit Units, 30 Credit Hours)
Syllabus: Concepts, history and foundations of bioethics. Ethics in research involving human beings (Resolution 196/96-CNS / MS). Ethics in research in specific thematic areas. Discussion in groups and seminars.
Etiopathogenesis of Major Protozoa of Amazonian Medical Interest (2 Credit Units, 30 Credit Hours)
Syllabus: Promoting the practical training and the theoretical deepening in themes involving the relation host - harmful agent related to protozoa, helminths, arthropods and venomous animals that cause or transmit human diseases, with emphasis to those found in the Amazon region.
Fundamentals of Bacteriology and the Etiopathogenesis of Diseases (2 Credit Units, 30 Credit Hours)
Syllabus: Principles and methods of etiological diagnosis of diseases caused by bacteria. Host-parasite-environment relationship in bacterial diseases. Bacterial cell structure and morphology. Nutrition and growth. Bacterial metabolism. Bacterial genomics and proteomics. Bacterial taxonomy. Normal flora of the human body. Mechanisms of pathogenicity of bacteria. Mechanisms of defense of the host. Bacteriological diagnosis. Origin and structure of the main bacterial agents. Mechanisms of action of antibacterials. Spectrum of action and indication of antibacterials. Bacterial resistance to drugs. Laboratory control of the treatment of bacterial infections. Epidemiology of bacterial infections. Sterilization and desifection. Staphilococcus. Streptococcus. Neisseria. Corynebacterium. Listeria. Hemophilus. Bordetella. Brucella. General information about enterobacteria. Escherichia. Salmonella and Shigella. Vibrio. Pseudomonas. General information about anaerobes. Anaerobic bacteria of greater clinical significance. Mycobacteria and Norcadias. Other bacteria of medical importance in the Amazon.
Fundamentals of Cell Biology and Tropical Diseases (3 Credit Units, 45 Credit Hours)
Syllabus: This subject is aimed at the knowledge of Cell Biology in the context of Tropical Medicine. The goal is to relate the modern knowledge of cell biology to understanding the problems related to infectious-contagious diseases. Introduction to cell study. Cells and genomes. The universal characteristics of cells on Earth. The diversity of genomes, the tree of life. Genetic information in eukaryotes. Cell chemistry and biosynthesis. The chemical components of the cell. Catalysis and the use of energy by cells. How cells get energy from food. The shape and structure of proteins. The function of proteins.
Fundamentals of Neurosciences and the Study of TD and Pathologies (2 Credit Units, 30 Credit Hours)
Syllabus: Cellular biology of neurons: structure of the neuron and its relation to function, neuronal cytoskeleton, axoplasmic transport. Cellular biology of glia: glial cells of the central nervous system, glial cells of the peripheral nervous system, functional role of glial cells. Neural mechanisms for the transmission of information: ionic bases of the membrane potential, diffusion and active transport of ions through the plasma membrane, resting potential, action potential, propagation of action potential, synaptic transmission. Sensory receptors, sensory transduction, sensory coding. Muscle contraction, motor unit. Rabies, axoplasmic transport, central nervous system invasion and superior nervous functions: etiological agents, hosts and transmission, clinical characteristics and types of rabies, pathogenesis, diagnosis, prevention, control, perpetuation and re-emergence. Arboviroses and viral encephalitis. Ocular involvement in dengue. Herpes simplex and herpetic encephalitis: epidemiology, structure and replication, neurovirulence, latent infections, pathology and pathogenesis, diagnosis, clinical manifestations of the disease, prevention of infections, treatment, herpes simplex encephalitis. Leprosy and the peripheral nervous system: global situation, epidemiology, bacteriology, disease classification, diagnosis, treatment, thalidomide as a new therapeutic agent, vaccination, leprosy reactions, treatment of reactions, prevention of incapacitation and rehabilitation. Bacterial meningitis. Toxoplasmosis and the visual system. Protozooses with central nervous system involvement. Cerebral malaria: in vivo models, in vitro models, experimental results, perspectives. Exposure to neurotoxic pollutants: mercury neurotoxicity, sensory impairment, motor control impairment, memory impairment, and other upper nervous functions.
Genetics of Microorganisms (3 Credit Units, 45 Credit Hours)
Syllabus: Structure of nucleic acids and gene expression. Bacterial and viral genomes and their replication processes. Gene recombination. Gene transfer during bacterial reproduction. Use of microbial genomes for diagnosis; Genome sequencing projects. Genetic data and the internet. Molecular biology of protozoa. Seminars and discussion in groups on the mechanisms of infection and bacterial resistance to antibiotics.
Immunology Applied to Tropical Diseases (3 Credit Units, 45 Credit Hours)
Syllabus: Concepts in immunology. Methods of studies of immune diseases. Inborn immunity. Adaptive immunity. Cells of the immune response. Humoral immunity. Antibodies. Cytokines. Major histocompatibility complex (MHC). Processing and presentation of antigens. Effector mechanisms of immune responses. Immunity to viruses. Immunity to bacteria. Immunity to fungi. Immunity to helminths and protozoa. AIDS and tropical diseases.
Methods of Etiological Characterization and Laboratory Diagnosis of Dts (2 Credit Units, 30 Credit Hours)
Syllabus: Fundamentals of molecular biology and immunology. Main methods of laboratory diagnosis: direct and indirect. Fundamentals of DNA technology and importance of DNA cloning in the diagnosis of microorganisms. DNA sequencing in the characterization of species of parasites, viruses, bacteria and fungi. Isoenzyme electrophoresis. Seminars, critical evaluation and discussion of the diagnostic value of the different techniques and their applicability to the reality of the Amazon region.
Participation in Seminars of the Center of Tropical Medicine (1 Credit Unit, 15 Credit Hours)
Syllabus: Participation in seminars given by researchers and masters in the lines of research and topics covered in the Tropical Diseases Graduate Program.
Pathology of Tropical Diseases (3 Credit Units, 45 Credit Hours)
Syllabus: Concepts in pathology. Methods of study in pathology. General mechanisms of cell injury. Cell death. Cellular lesions induced by infectious agents. Immunopathology of parasite-host interaction. Pathology of tropical diseases of viral nature. Pathology of tropical diseases of fungal nature. Pathology of tropical diseases of bacterial nature. Pathology of tropical diseases induced by protozoa and helminths. Molecular biology in the study of pathology. Immunohistochemistry: concept and applications.
Teaching Practice in Health Sciences (2 Credit Units, 30 Credit Hours)
Seminars on Health and Environment (2 Credit Units, 30 Credit Hours)
Syllabus: Introduction to environmental health. Man and the various environmental compartments Inter-relation, highlighting health prevention. Legislation of CONAMA. Study of the main environmental problems of the state of Pará and its consequences for human health. Contamination of water, emphasizing slaughterhouses and cemeteries. Soil contamination, pesticides (organochlorines, organophosphates, carbamates and pyrethroids), heavy metals (mercury, arsenic, aluminum and manganese). Air contamination: primary atmospheric pollutants (highlighting carbon monoxide), secondary air pollutants and major atmospheric phenomena of toxicological concern (acid rain, ozone depletion, greenhouse effect and thermal inversion). Interactions resulting from the concomitant occurrence of tropical pathologies and pollution by chemical agents in the Amazon.
Special Topics in Health Dermatology (2 Credit Units, 30 Credit Hours)
Syllabus: Hansenology: epidemiology and control in the world and in Brazil. Etiopathogenic and bacteriological aspects. Immunopathology. Diagnostic tests. Clinical Aspects. Neural damage and disability prevention. Therapeutic perspectives of reactional states. Leprosy and HIV / AIDS. Epidemiology and STD control / syndromic approach. Syphilis. Herpes simplex and HPV. Soft cancer and donovanose. Gonococcal and non-gonococcal urethritis. STD and HIV / AIDS.
Special Topics in Health Dermatology: Hansenology and STD (2 Credit Units, 30 Credit Hours)
Syllabus: Hansenology: epidemiology and control in the world and in Brazil. Etiopathogenic and bacteriological aspects. Immunopathology. Diagnostic tests. Clinical Aspects. Neural damage and disability prevention. Therapeutic perspectives of reactional states. Leprosy and HIV / AIDS. Epidemiology and STD control / syndromic approach. Syphilis. Herpes simplex and HPV. Soft cancer and donovanose. Gonococcal and non-gonococcal urethritis. STD and HIV / AIDS.
Special Topics in Medical Virology (2 Credit Units, 30 Credit Hours)
Syllabus: Concepts and classification of viral agents. Nomenclature. Genomic organization and virus nomenclature. Viral multiplication. Pathogenesis of viral infection. Laboratory diagnosis of viral infections. Epidemiology and prophylaxis. Viruses and tumors. Viruses of the skin and mucous membranes. Viruses of the eyeball. Respiratory viruses. Viral diarrhea. Liver viruses. Lymphatic and glandular viruses. Viruses of the nervous system. Viral haemorrhagic fevers.